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- Title
Case report: Ponatinib as a bridge to CAR-T cells and subsequent maintenance in a patient with relapsed/refractory Philadelphia-like acute lymphoblastic leukemia.
- Authors
Giglio, Fabio; Campodonico, Edoardo; Lorentino, Francesca; Noviello, Maddalena; Xue, Elisabetta; Greco, Raffaella; Lazzari, Lorenzo; Bruno, Alessandro; Lupo Stanghellini, Maria Teresa; Carrabba, Matteo Giovanni; La Starza, Roberta; Casucci, Monica; Bonini, Chiara; Chiaretti, Sabina; Peccatori, Jacopo; Foà, Robin; Ciceri, Fabio
- Abstract
Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) constitutes a heterogeneous subset of ALL with a uniformly unfavorable prognosis. The identification of mutations amenable to treatment with tyrosine kinase-inhibitors (TKIs) represents a promising field of investigation. We report the case of a young patient affected by relapsed/refractory Ph-like ALL treated with chimeric antigen receptor T (CAR-T) cells after successful bridging with compassionate-use ponatinib and low-dose prednisone. We restarted low-dose ponatinib maintenance three months later. Twenty months later, measurable residual disease negativity and B-cell aplasia persist. To the best of our knowledge, this is the first case reporting the use of ponatinib in Ph-like ALL as a bridge to and maintenance after CAR-T cell therapy
- Publication
Frontiers in Oncology, 2023, Vol 12, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2022.1100105