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- Title
Signature channels of excitability no more: L-type channels in immune cells.
- Authors
Davenport, Bennett; Yuan Li; Heizer, Justin W.; Schmitz, Carsten; Perraud, Anne-Laure
- Abstract
Although the concept of Ca2+ as a universal messenger is well established, it was assumed that the regulatory mechanisms of Ca2+-signaling were divided along the line of electric excitability. Recent advances in molecular biology and genomics have, however, provided evidence that non-excitable cells such as immunocytes also express a wide and diverse pool of ion channels that does not differ as significantly from that of excitable cells as originally assumed. Ion channels and transporters are involved in virtually all aspects of immune response regulation, from cell differentiation and development to activation, and effector functions such as migration, antibody-secretion, phagosomal maturation, or vesicular delivery of bactericidal agents. This comprises TRP channel family members, voltage- and Ca2+-gated K+- and Na+-channels, as well as unexpectedly, components of the Ca2+V1-subfamily of voltage-gated L-type Ca -channels, originally thought to be signature molecules of excitability. This article provides an overview of recent observations made in the field of CaV1 L-type channel function in the immune context, as well as presents results we obtained studying these channels in B-lymphocytes.
- Subjects
ELECTRONIC excitation; MOLECULAR biology; GENOMICS; IMMUNOCYTOCHEMISTRY; ION channels; CELL differentiation
- Publication
Frontiers in Immunology, 2015, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2015.00375