We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The <sup>13</sup>C-caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy.
- Authors
PARK, G. J.‐H.; KATELARIS, P. H.; JONES, D. B.; SEOW, F.; LIN, B. P. C.; LE COUTEUR, D. G.; NGU, M. C.
- Abstract
: The 13C-caffeine breath test is a non-invasive, quantitative test of liver function. : To determine the utility of the 13C-caffeine breath test in chronic hepatitis B virus and its ability to monitor response to lamivudine. : Forty-eight chronic hepatitis B virus patients and 24 controls underwent the 13C-caffeine breath test. In 28 patients commenced on lamivudine, 13C-caffeine breath tests were performed at 1 week ( n = 12) and after 1 year of therapy. : Patients with Metavir F0–1 fibrosis (2.30 ± 1.02 Δ‰ per 100 mg caffeine) had a 13C-caffeine breath test similar to controls (2.31 ± 0.85, P = 0.96). However, patients with F2–3 fibrosis (1.59 ± 0.78, P = 0.047) and cirrhotic patients (0.99 ± 0.33, P = 0.001) had a decreased 13C-caffeine breath test. Fibrosis correlated best with the 13C-caffeine breath test ( rs = −0.62, P < 0.001). The 13C-caffeine breath test independently predicted significant (F ≥ 2) and advanced (F ≥ 3) fibrosis and yielded the greatest area under the receiver operating characteristic curve (0.91 ± 0.04) for predicting advanced fibrosis. The 13C-caffeine breath test was unaltered by 1 week of lamivudine but improved by 61% ( P < 0.001) in responders to long-term lamivudine, whereas in those with viraemia and elevated alanine aminotransferase, values remained stable or deteriorated. : The 13C-caffeine breath test distinguishes chronic hepatitis B virus-related fibrosis and detects improvement in liver function in response to long-term lamivudine.
- Subjects
CAFFEINE; BREATH tests; FIBROSIS; COLLAGEN diseases; HEPATITIS B; LIVER diseases
- Publication
Alimentary Pharmacology & Therapeutics, 2005, Vol 22, Issue 5, p395
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2005.02623.x