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- Title
Decreased Resting-State Interhemispheric Functional Connectivity in Medication-Free Obsessive-Compulsive Disorder.
- Authors
Jia, Cuicui; Ou, Yangpan; Chen, Yunhui; Li, Ping; Lv, Dan; Yang, Ru; Zhong, Zhaoxi; Sun, Lei; Wang, Yuhua; Zhang, Guangfeng; Guo, Hong; Sun, Zhenghai; Wang, Wei; Wang, Yefu; Wang, Xiaoping; Guo, Wenbin
- Abstract
Objective: Decreased homotopic connectivity of brain networks such as the cortico-striato-thalamo-cortical (CSTC) circuits may contribute to the pathophysiology of obsessive-compulsive disorder (OCD). However, little is known about interhemispheric functional connectivity (FC) at rest in OCD. In this study, the voxel-mirrored homotopic connectivity (VMHC) method was applied to explore interhemispheric coordination at rest in OCD. Methods: Forty medication-free patients with OCD and 38 sex-, age-, and education level-matched healthy controls (HCs) underwent a resting-state functional magnetic resonance imaging. The VMHC and support vector machine (SVM) methods were used to analyze the data. Results: Patients with OCD had remarkably decreased VMHC values in the orbitofrontal cortex, thalamus, middle occipital gyrus, and precentral and postcentral gyri compared with HCs. A combination of the VMHC values in the thalamus and postcentral gyrus could optimally distinguish patients with OCD from HCs. Conclusions: Our findings highlight the contribution of decreased interhemispheric FC within and outside the CSTC circuits in OCD and provide evidence to the pathophysiology of OCD.
- Subjects
FUNCTIONAL connectivity; OBSESSIVE-compulsive disorder; FUNCTIONAL magnetic resonance imaging; SUPPORT vector machines
- Publication
Frontiers in Psychiatry, 2020, Vol 11, pN.PAG
- ISSN
1664-0640
- Publication type
Article
- DOI
10.3389/fpsyt.2020.559729