We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Allogeneic hematopoietic cell transplantation for metastatic breast cancer.
- Authors
Ueno, N. T.; Rizzo, J. D.; Demirer, T.; Cheng, Y. C.; Hegenbart, U.; Zhang, M.-J.; Bregni, M.; Carella, A.; Blaise, D.; Bashey, A.; Bitran, J. D.; Bolwell, B. J.; Elfenbein, G. J.; Fields, K. K.; Freytes, C. O.; Gale, R. P.; Lazarus, H. M.; Champlin, R. E.; Stiff, P. J.; Niederwieser, D.
- Abstract
We reviewed 66 women with poor-risk metastatic breast cancer from 15 centers to describe the efficacy of allogeneic hematopoietic cell transplantation (HCT). Median follow-up for survivors was 40 months (range, 3–64). A total of 39 patients (59%) received myeloablative and 27 (41%) reduced-intensity conditioning (RIC) regimens. More patients in the RIC group had poor pretransplant performance status (63 vs 26%, P=0.002). RIC group developed less chronic GVHD (8 vs 36% at 1 year, P=0.003). Treatment-related mortality rates were lower with RIC (7 vs 29% at 100 days, P=0.03). A total of 9 of 33 patients (27%) who underwent immune manipulation for persistent or progressive disease had disease control, suggesting a graft-vs-tumor (GVT) effect. Progression-free survival (PFS) at 1 year was 23% with myeloablative conditioning and 8% with RIC (P=0.09). Women who developed acute GVHD after an RIC regimen had lower risks of relapse or progression than those who did not (relative risk, 3.05: P=0.03), consistent with a GVT effect, but this did not affect PFS. These findings support the need for preclinical and clinical studies that facilitate targeted adoptive immunotherapy for breast cancer to explore the benefit of a GVT effect in breast cancer.Bone Marrow Transplantation (2008) 41, 537–545; doi:10.1038/sj.bmt.1705940; published online 17 December 2007
- Subjects
GRAFT versus host disease; BREAST cancer; DISEASES in women; HEMATOPOIETIC system; TRANSPLANTATION of organs, tissues, etc.; MEDICAL care
- Publication
Bone Marrow Transplantation, 2008, Vol 41, Issue 6, p537
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705940