We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Allogeneic haematopoietic stem cell transplant in Philadelphia-positive acute lymphoblastic leukaemia.
- Authors
Fielding, A K; Goldstone, A H
- Abstract
ALL in which the Philadelphia (Ph) chromosome is detected is one of the few diseases in which there is almost unequivocal agreement that a matched sibling allogeneic haematopoietic stem cell transplant in first CR is the most appropriate therapy for patients within certain age limits. Extension of allogeneic stem cell transplant to patients without matched sibling donors or to older individuals is increasingly possible due to unrelated donors, umbilical cord blood and reduced-intensity conditioning regimens. Here, we carefully review evidence supporting current practice and examine recent evidence relating to the use of newer allogeneic transplant technologies in Ph-pos ALL. We explore the burgeoning literature on the role of tyrosine kinase inhibitors in this disease and summarize their impact on the transplant practice.Bone Marrow Transplantation (2008) 41, 447–453; doi:10.1038/sj.bmt.1705904; published online 29 October 2007
- Subjects
HEMATOPOIETIC stem cell transplantation; LYMPHOBLASTIC leukemia treatment; CHROMOSOMES; PROTEIN-tyrosine kinase inhibitors; PATIENTS
- Publication
Bone Marrow Transplantation, 2008, Vol 41, Issue 5, p447
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705904