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- Title
Is redox signaling a feasible target for overcoming multidrug resistance in cancer chemotherapy?
- Authors
Polimeni, Manuela; Gazzano, Elena; Kopecka, Joanna; Bergandi, Lordana; Niso, Mauro
- Abstract
The article discusses research studies on the role of redox signaling in addressing multidrug resistance in chemotherapy. Topics cited include the main sources of reactive oxygen species, effect of changes in redox balance, expression of nuclear factor-erythroid 2 related factor 2 (Nrf2) in cancer cells, and implications of modulation of cellular redox levels.
- Subjects
MULTIDRUG resistance; DRUG resistance in cancer cells; CANCER chemotherapy; ANTINEOPLASTIC agents; ACTIVE oxygen in the body
- Publication
Frontiers in Pharmacology, 2014, Vol 5, p1
- ISSN
1663-9812
- Publication type
Opinion
- DOI
10.3389/fphar.2014.00286