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- Title
Effect of Graded Intravenous Doses of Urogastrone on Duodenal Bicarbonate Secretion in Conscious Rats: Evidence of a Dose-Response Pattern.
- Authors
Marotta, Francesco; Chui, De Hua; Zhong, Guo Gan; Safran, Patrick
- Abstract
In the present study, the effect of graded intravenous bolus injections of urogastrone, 0.5, 5, 25 and 50 μg/kg, on rat duodenal bicarbonate secretion was investigated. Perfused duodenal loops were prepared in rats in a strictly controlled fashion. After full recovery, different groups of rats were injected with intravenous graded bolus doses of urogastrone. During the following 45-min study period, duodenal pH and pCO2 were measured at 5-min intervals and bicarbonate secretion was calculated accordingly. Compared to controls, each dose of urogastrone caused a significant dose-response increase in duodenal bicarbonate secretion, measured either at each 5-min reading or as total 45-min output. These results provide the evidence that urogastrone may play a role in the humoral control of duodenal alkaline secretion. Copyright © 1990 S. Karger AG, Basel
- Publication
Digestion, 1990, Vol 47, Issue 2, p88
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000200481