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- Title
Current State of Carbohydrate Recognition and C-Type Lectin Receptors in Pneumocystis Innate Immunity.
- Authors
Kottom, Theodore J.; Carmona, Eva M.; Limper, Andrew H.
- Abstract
Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism's cell wall components including β-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/ Pneumocystis interactions.
- Subjects
PNEUMOCYSTIS pneumonia; NATURAL immunity; CARBOHYDRATES; IMMUNOCOMPROMISED patients; CELLULAR signal transduction
- Publication
Frontiers in Immunology, 2021, Vol 12, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2021.798214