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- Title
Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.
- Authors
Kenins, Linda; Gill, Jason W.; Holländer, Georg A.; Wodnar-Filipowicz, Aleksandra
- Abstract
T-cell production throughout life depends on efficient colonization and intrathymic expansion of BM-derived hematopoietic precursors. After irradiation-induced thymic damage, thymic recovery is facilitated by Flt3 ligand (FL), expressed by perivascular fibroblasts surrounding the thymic entry site of Flt3 receptor-positive progenitor cells. Whether intrathymic FL-Flt3 interactions play a role in steady-state replenishment of T cells remains unknown. Here, using competitive BM transplantation studies and fetal thymic organ cultures we demonstrated the continued numerical advantage of Flt3
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 1, p81
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200839213