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- Title
Identification of natural killer markers associated with fatal outcome in COVID-19 patients.
- Authors
Tarantino, Nadine; Litvinova, Elena; Samri, Assia; Soulie, Cathia; Morin, Véronique; Rousseau, Alice; Dorgham, Karim; Parizot, Christophe; Bonduelle, Olivia; Beurton, Alexandra; Miyara, Makoto; Ghillani, Pascale; Mayaux, Julien; Lhote, Raphael; Lacorte, Jean-Marc; Marcelin, Anne-Geneviève; Amoura, Zahir; Luyt, Charles-Edouard; Gorochov, Guy; Guihot, Amélie
- Abstract
Introduction: Increasing evidence has shown that coronavirus disease 19 (COVID-19) severity is driven by a dysregulated immunological response. Previous studies have demonstrated that natural killer (NK) cell dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of NK cell markers as a driver of death in the most critically ill patients. Methods: We enrolled 50 non-vaccinated hospitalized patients infected with the initial virus or the alpha variant of SARS-CoV-2 with moderate or severe illness, to evaluate phenotypic and functional features of NK cells. Results: Here, we show that, consistent with previous studies, evolution NK cells from COVID-19 patients are more activated, with the decreased activation of natural cytotoxicity receptors and impaired cytotoxicity and IFN-g production, in association with disease regardless of the SARS-CoV-2 strain. Fatality was observed in 6 of 17 patients with severe disease; NK cells from all of these patients displayed a peculiar phenotype of an activated memory-like phenotype associated with massive TNF-a production. Discussion: These data suggest that fatal COVID-19 infection is driven by an uncoordinated inflammatory response in part mediated by a specific subset of activated NK cells.
- Subjects
COVID-19; KILLER cells; SARS-CoV-2; CELLULAR evolution; CELL analysis
- Publication
Frontiers in Cellular & Infection Microbiology, 2023, p1
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2023.1165756