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- Title
Relationship between body-mass index and serum folate concentrations in pregnant women.
- Authors
Kim, H; Hwang, J-Y; Kim, K-N; Ha, E-H; Park, H; Ha, M; Lee, K-Y; Hong, Y-C; Tamura, T; Chang, N
- Abstract
The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy (P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations.
- Subjects
BODY mass index; FOLIC acid; PREGNANT women; MICRONUTRIENTS; FETAL development; HEALTH outcome assessment; LONGITUDINAL method
- Publication
European Journal of Clinical Nutrition, 2012, Vol 66, Issue 1, p136
- ISSN
0954-3007
- Publication type
Article
- DOI
10.1038/ejcn.2011.160