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- Title
Biocatalytic Asymmetric Synthesis of Unnatural Amino Acids through the Cascade Transfer of Amino Groups from Primary Amines onto Keto Acids.
- Authors
Park, Eul‐Soo; Dong, Joo‐Young; Shin, Jong‐Shik
- Abstract
Flee to the hills: An unfavorable equilibrium in the amino group transfer between amino acids and keto acids catalyzed by α‐transaminases was successfully overcome by coupling with a ω‐transaminase reaction as an equilibrium shifter, leading to efficient asymmetric synthesis of diverse unnatural amino acids, including L‐tert‐leucine and D‐phenylglycine.
- Subjects
AMINO acid synthesis; AMINO group; ENZYMES; AMINOTRANSFERASES; CHEMICAL yield
- Publication
ChemCatChem, 2013, Vol 5, Issue 12, p3538
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.201300571