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- Title
Relationship between a wide range of alcohol consumptions, components of the insulin-like growth factor system and adiponectin.
- Authors
Dal Maso, L.; La Vecchia, C.; Augustin, L. S. A.; Mantzoros, C. S.; Kendall, C. W. C.; Franceschi, S.
- Abstract
Objective:To explore the relation between a wide range of alcohol consumptions and levels of the components of insulin-like growth factor system (IGFs) and adiponectin in humans.Design:A cross-sectional study using controls from a case–control study on ovarian and endometrial cancer.Settings:The study included women hospitalized between 1999 and 2002 in Pordenone, Italy.Subjects:One hundred and eight cancer-free (controls) with a median age of 61 years (range 29–79 years), admitted for acute conditions unrelated to gynecologic, hormonal or metabolic disorders or diseases leading to dietary modifications.Interventions:Levels of IGF-I (total and free), total IGF-II, IGF-binding protein 1 (IGFBP-1), IGFBP-3 and adiponectin were individually measured, and their distributions across strata of alcohol consumption were tested by the Kruskal–Wallis statistic.Results:Median concentrations of total IGF-I were higher (P<0.01) in women reporting low (151 ng/ml) or no alcohol consumption (134 ng/ml) compared to drinkers of 12–23 g/day (103 ng/ml) or 24 g/day (118 ng/ml). Median concentrations were higher (P=0.05) for IGFBP-3 in non-drinkers (2333 ng/ml) and in light drinkers (2647 ng/ml) compared to drinkers of 24 g/day (2090 ng/ml). No statistically significant difference emerged for other IGFs across levels of alcohol intakes. Adiponectin was slightly lower for non-drinkers, compared to all drinkers categories.Conclusions:Our study suggests that alcohol consumption is related to circulating levels of components of the IGF system and adiponectin. These results may have a potential impact on the prevention of several chronic diseases.Sponsorship:Italian Association for Research on Cancer, Milan, Italy, and Italian League against Tumours, Milan, Italy.European Journal of Clinical Nutrition (2007) 61, 221–225. doi:10.1038/sj.ejcn.1602519; published online 13 September 2006
- Subjects
PORDENONE (Italy); ITALY; ALCOHOL drinking; SOMATOMEDIN; GROWTH factors; ENDOMETRIAL cancer; DIET therapy
- Publication
European Journal of Clinical Nutrition, 2007, Vol 61, Issue 2, p221
- ISSN
0954-3007
- Publication type
Article
- DOI
10.1038/sj.ejcn.1602519