We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The effects of nanomicelle of curcumin on the matrix metalloproteinase MMP-2, 9) activity and expression in patients with coronary artery disease (CAD): A randomized controlled clinical trial.
- Authors
Mogharrabi, Marzieh; Rahimi, Hamid Reza; Hasanzadeh, Shima; Dastani, Mostafa; Kazemi-Oskuee, Reza; Akhlaghi, Saeed; Soukhtanloo, Mohammad
- Abstract
BACKGROUND: Coronary artery disease (CAD) is the most common type of cardiovascular disease . Increasing the expression and activity of matrix metalloproteinases (MMPs) facilitates vascular remodeling and cardiovascular complications. Curcumin (the active ingredient of turmeric) is a potent natural anti-inflammatory agent, with cardiovascular protective effects. The present study was a clinical trial for investigating the effects of curcumin on activity and gene expression of MMP-2 and MMP-9 in patients with CAD. METHODS: In this study, 70 patients with CAD (with 40%-50% stenosis) were randomly divided into two groups of curcumin (80 mg nanomicelle per day) and placebo. The intervention lasted 3 months. The activity levels of MMP-2 and MMP-9 in serum samples of patients were measured using gelatin zymography assay before and after the intervention. MMP-2 and MMP- 9 gene expression in peripheral blood mononuclear cells (PBMCs) was also analyzed using realtime polymerase chain reaction (PCR). Statistical significance was set at P < 0.0500. RESULTS: After 3 months of medication, the expression of MMP-9 produced by PBMCs significantly decreased in the curcumin group (0.811 ± 0.25) in comparison with the placebo group (2.23 ± 0.94) (P < 0.0001). Furthermore, the zymographic analysis showed that the administration of curcumin significantly inhibited the activity levels of MMP-2 (12469.7 ± 5308.64 pixels) and MMP-9 (14007.2 ± 5371.67 pixels) in comparison with that in patients receiving placebo (MMP-2: 17613.8 ± 5250.68 pixels; MMP-9: 20010.1 ± 3259.37 pixels) (P < 0.0500). CONCLUSION: Our results show that curcumin can significantly reduce the expression and activity of MMP-2 and MMP-9. Because of the anti-inflammatory effects of curcumin, this compound can be considered as a new strategy for the prevention of cardiovascular events.
- Subjects
CLINICAL trials; CORONARY disease; MATRIX metalloproteinases; POLYMERASE chain reaction; VASCULAR remodeling
- Publication
ARYA Atherosclerosis, 2020, Vol 16, Issue 3, p136
- ISSN
1735-3955
- Publication type
Article
- DOI
10.22122/arya.v16i3.1938