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- Title
Selective internal radiation therapy (SIRT) as treatment for hepatic metastases of uveal melanoma: a Finnish nation-wide retrospective experience.
- Authors
Tulokas, Sanni; Mäenpää, Hanna; Peltola, Erno; Kivelä, Tero; Vihinen, Pia; Virta, Aku; Mäkelä, Siru; Kallio, Raija; Hernberg, Micaela
- Abstract
Background: In Finland, selective internal radiation therapy (SIRT) is at present the preferred first-line loco-regional therapy for uveal melanoma patients with hepatic metastases not suitable for surgery. We retrospectively evaluate the outcome and safety of SIRT in this group of patients. Material and methods: Yttrium-90 microspheres were delivered via the hepatic artery into the circulation of metastases from uveal melanoma in 18 patients with a predicted life expectancy of more than three months in three Finnish tertiary referral centers between November 2010 and December 2015. Progression-free survival (PFS), toxicity and overall survival (OS) were evaluated. Patients with historical uveal melanoma without extrahepatic metastases, who had received systemic chemotherapy as first-line treatment for their hepatic metastases at the Helsinki University Hospital between January 2006 and May 2010, were used as a historical control group. Results: Partial response and stable disease were observed in three (17%) and eight (44%) patients, respectively; one patient was not evaluable for response. Median PFS after SIRT was 5.6 (range, 1.3-40.8) months. Median OS after SIRT was 13.5 (range, 3.6-44.8) months compared with 10.5 (range, 3.0-16.5; p = .047) months for the historical chemotherapy group. Among patients who received SIRT as first-line treatment, the median OS was 18.7 (range, 8.2-44.8) months, significantly longer than that of the chemotherapy group (10.5 months, p = .017). There were no treatment-related deaths. Toxicity was mainly WHO grade 1-2 and self-limited. Conclusion: SIRT is a feasible and safe treatment for liver metastases in patients with uveal melanoma.
- Subjects
FINLAND; HEPATIC artery surgery; RADIOISOTOPE therapy; ACADEMIC medical centers; CANCER chemotherapy; DRUG toxicity; LIFE expectancy; LIVER tumors; MELANOMA; METASTASIS; PATIENT safety; UVEA; TREATMENT effectiveness; RETROSPECTIVE studies; RADIOEMBOLIZATION; TERTIARY care; DISEASE complications; PROGNOSIS; TUMORS
- Publication
Acta Oncologica, 2018, Vol 57, Issue 10, p1373
- ISSN
0284-186X
- Publication type
Article
- DOI
10.1080/0284186X.2018.1465587