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- Title
Clinical and Pathological Features of Chinese Patients with Type 2 Diabetes, Biopsy-Proven Diabetic Kidney Disease, and Rapid eGFR Decline.
- Authors
Qin, Chunmei; Wang, Yiting; Zhao, Lijun; Zhang, Junlin; Ren, Honghong; Zou, Yutong; Wu, Yucheng; Wang, Tingli; Zhao, Yuancheng; Zhang, Rui; Xu, Huan; Zhang, Jie; Cooper, Mark E; Liu, Fang
- Abstract
Compared with patients who did not progress to ESRD, patients who progressed to ESRD had lower baseline eGFR (49 [35, 65] vs 79 [57, 99] mL/min/1.73 m SP 2 sp , I P i < 0.001), lower serum albumin (31.1 ± 7.0 vs 35.4 ± 6.9 g/L, I P i = 0.003), and lower hemoglobin levels (106 ± 20 vs 125 ± 27 g/L, I P i < 0.001), but higher proteinuria (6.1 [3.6, 9.6] vs 2.9 [1.8, 6.8] g/24 h, I P i = 0.002) and total cholesterol levels (5.63 ± 1.82 vs 5 ± 1.20 mmol/L, I P i = 0.046). In a recent study involving Japanese DKD patients, the clinicopathological features of fast estimated glomerular filtration rate (eGFR) decliners were evaluated.[9] However, the risk factors for progression to ESRD in rapid eGFR decliners were not analyzed. The presence of glomerular lesions is considered to be the main factor associated with DKD progression.[29],[30] However, Okada et al[31] provided evidence that interstitial lesions (not glomerular and vascular lesions) were significant predictors of renal prognosis in DKD patients. Therefore, to better understand the course of DKD in Chinese patients, we conducted a retrospective study of type 2 diabetes patients with biopsy-proven DKD and rapid eGFR decline.
- Subjects
DIABETIC nephropathies; TYPE 2 diabetes; PROPORTIONAL hazards models; EPIDERMAL growth factor receptors; CHINESE people; LOGISTIC regression analysis; HYPERGLYCEMIA
- Publication
Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2022, Vol 15, p2847
- ISSN
1178-7007
- Publication type
Article
- DOI
10.2147/DMSO.S381052