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- Title
Prevalence and molecular epidemiology of ceftaroline non-susceptible methicillin-resistant Staphylococcus aureus isolates, first clinical report from Iran.
- Authors
Khoshbayan, Amin; Shariati, Aref; Ghaznavi-Rad, Ehsanollah; van Belkum, Alex; Darban-Sarokhalil, Davood
- Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major pathogens in Iran with a high prevalence and a high level of antibiotic resistance. Ceftaroline is a fifth generation cephalosporin binding and inhibiting penicillin binding protein (PBP2a). In the present study, 228 clinical MRSA isolates were collected from four cities of Iran and their susceptibility to ceftaroline was evaluated by E-test and the disk diffusion method. Our results showed a high susceptibility rate (97.3%) to ceftaroline in MRSA strains from Iran. Six isolates were found to be ceftaroline non-susceptible (CPT-NS) with Minimum inhibitory concentration (MIC) ≥2 µg/mL. All CPT-NS isolates were isolated from blood and tracheal aspirate and belonged to SCC mec type III as well as agr type I and were all susceptible to vancomycin. Out of six isolates, three, two and one belonged to spa type t030, t4864, and t969, respectively. Vancomycin, quinupristin/dalfopristin, linezolid, chloramphenicol, and tigecycline were the most active agents against CPT-NS isolates. Due to the broad-spectrum activity and low toxicity of ceftaroline as well as the increased rate of vancomycin resistance among MRSA strains in recent years, ceftaroline can be considered as a novel approach to treat MRSA-induced infections.
- Subjects
IRAN; MOLECULAR epidemiology; METHICILLIN-resistant staphylococcus aureus; CEFTAROLINE; VANCOMYCIN resistance; CHLORAMPHENICOL; DRUG resistance in bacteria
- Publication
Acta Microbiologica et Immunologica Hungarica, 2020, Vol 67, Issue 4, p228
- ISSN
1217-8950
- Publication type
Article
- DOI
10.1556/030.2020.01273