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- Title
T Cell Responses to the RTS,S/AS01<sub>E</sub> and RTS,S/AS02<sub>D</sub> Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children.
- Authors
Ansong, Daniel; Asante, Kwaku P.; Vekemans, Johan; Owusu, Sandra K.; Owusu, Ruth; Brobby, Naana A. W.; Dosoo, David; Osei-Akoto, Alex; Osei-Kwakye, Kingsley; Asafo-Adjei, Emmanuel; O.^Boahen, Kwadwo; Sylverken, Justice; Adjei, George; Sambian, David; Apanga, Stephen; Kayan, Kingsley; Janssens, Michel H.; Lievens, Marc J. J.; Olivier, Aurelie C.; Jongert, Erik
- Abstract
Background: The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa. RTS,S formulated with the liposome based adjuvant AS01E or the oil-in-water based adjuvant AS02D induces P. falciparum circumsporozoite (CSP) antigen-specific antibody and T cell responses which have been associated with protection in the experimental malaria challenge model in adults. Methods: This study was designed to evaluate the safety and immunogenicity induced over a 19 month period by three vaccination schedules (0,1-, 0,1,2- and 0,1,7-month) of RTS,S/AS01E and RTS,S/AS02D in children aged 5-17 months in two research centers in Ghana. Control Rabies vaccine using the 0,1,2-month schedule was used in one of two study sites. Results: Whole blood antigen stimulation followed by intra-cellular cytokine staining showed RTS,S/AS01E induced CSP specific CD4 T cells producing IL-2, TNF-α, and IFN-γ. Higher T cell responses were induced by a 0,1,7-month immunization schedule as compared with a 0,1- or 0,1,2-month schedule. RTS,S/AS01E induced higher CD4 T cell responses as compared to RTS,S/AS02D when given on a 0,1,7-month schedule. Conclusions: These findings support further Phase III evaluation of RTS,S/AS01E. The role of immune effectors and immunization schedules on vaccine protection are currently under evaluation.
- Subjects
GHANA; PLASMODIUM falciparum; MALARIA; T cells; PREVENTIVE pediatrics; VACCINATION of children; IMMUNIZATION; CYTOKINES; RESEARCH institutes; VACCINATION
- Publication
PLoS ONE, 2011, Vol 6, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0018891