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- Title
Anti-Angiogenic and Anti-Inflammatory Effects of SERPINA3K on Corneal Injury.
- Authors
Xiaochen Liu; Zhirong Lin; Tong Zhou; Ronrong Zong; Hui He; Zhen Liu; Jian-xing Ma; Zuguo Liu; Yueping Zhou
- Abstract
SERPINA3K is a member of the serine proteinase inhibitor (SERPIN) family. Here we evaluated the therapeutic effects of SERPINA3K on neovascularization and inflammation in a rat cornea alkali burn model that is commonly employed to study corneal wounding. Topical treatment of the injured rat cornea with SERPINA3K (20μmg/eye/day) for 7 days significantly decreased the neovascular area, compared with the groups treated with BSA or PBS. The SERPINA3K treatment also ameliorated the corneal inflammation as evaluated by the inflammatory index. Furthermore, SERPINA3K enhanced the recovery of corneal epithelium after the alkali injury. Toward the mechanism of action, SERPINA3K down-regulated the expression of the pro-angiogenic and pro-inflammatory factors, vascular endothelial growth factor and tumor necrosis factor-a and up-regulated the expression of the anti-angiogenic factor, pigment epithelium-derived factor. SERPINA3K specifically inhibited growth of vascular endothelial cells. Meanwhile, SERPINA3K significantly up-regulated the expression of EGFR in the corneal epithelium. These findings suggest that SERPINA3K has therapeutic potential for corneal inflammation and NV.
- Subjects
SERINE proteinases; CORNEA injuries; CILIA &; ciliary motion; ANTERIOR eye segment; BLOOD-vessel development; TUMOR necrosis factors; PROTEINASES
- Publication
PLoS ONE, 2011, Vol 6, Issue 1, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0016712