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- Title
MicroRNA-634 alters nerve apoptosis via the PI3K/Akt pathway in cerebral infarction.
- Authors
Chang, Yajun; Huang, Wei; Sun, Qian; Li, Suli; Yan, Zhongkai; Wang, Qiumin; Liu, Xiumin
- Abstract
In the present study, the role and mechanism of microRNA-634 (miRNA-634) in the adjustment of nerve inflammation and apoptosis in cerebral infarction were investigated. In a cerebral infarction rat model, the expression of miRNA-634 was increased, compared with that in the normal control group. The upregulated expression of miRNA-634 in an in vitro model of cerebral infarction increased cell apoptosis and the protein expression of capsase-3/B-cell lymphoma 2-associated X protein (Bax) via inactivation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. The down-regulation of miRNA-634 enhanced cell growth and inhibited cell apoptosis in the in vitro model of cerebral infarction through induction of the PI3K/Akt pathway. Subsequently, a PI3K inhibitor was used to inhibit the expression of PI3K in the in vitro model of cerebral infarction via the downregulation of miRNA-634, which showed that cell apoptosis and the protein expression of capsase-3/Bax were also increased. A PI3K agonist reduced the effects of the upregulation of miRNA-634 in the in vitro model of cerebral infarction. In conclusion, the data obtained demonstrated the possible future use of miRNA-634 as a therapeutic target in cerebral infarction through the PI3K/Akt pathway.
- Publication
International Journal of Molecular Medicine, 2018, Vol 42, Issue 4, p2145
- ISSN
1107-3756
- Publication type
Article
- DOI
10.3892/ijmm.2018.3777