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- Title
Variable Presentation of Disseminated Nontuberculous Mycobacterial Infections in a Family with an Interferon-γ Receptor Mutation.
- Authors
Jin-Young Han; Rosenzweig, Sergio D.; Church, Joseph A.; Holland, Steven M.; Ross, Lawrence A.
- Abstract
A previously healthy 13-year-old child who had disseminated Mycobacterium avium infection is described. Further history revealed disseminated mycobacterial infections in the patient's father and uncle, starting at 9 years old and 1 year old, respectively. Autosomal dominant interferon--y receptor mutation was subsequently identified. Clinical variability among the affected members of the same family is consistent with previous reports suggesting substantial variability in the clinical course of this disorder. A previously healthy 13-year-old child who had disseminated Mycobacterium avium infection is described. Further history revealed disseminated mycobacterial infections in the patient's father and uncle, starting at 9 years old and 1 year old, respectively. Autosomal dominant interferon-&gama; receptor mutation was subsequently identified. Clinical variability among the affected members of the same family is consistent with previous reports suggesting substantial variability in the clinical course of this disorder.
- Subjects
TUBERCULOSIS patients; MYCOBACTERIAL diseases; INTERFERONS; GENETIC mutation; BACTERIAL diseases; ANTIVIRAL agents
- Publication
Clinical Infectious Diseases, 2004, Vol 39, Issue 6, p868
- ISSN
1058-4838
- Publication type
Report
- DOI
10.1086/423804