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- Title
Inverted urothelial papilloma and urothelial carcinoma with inverted growth are histologically and molecularly distinct entities.
- Authors
Almassi, Nima; Pietzak, Eugene J; Sarungbam, Judy; Tickoo, Satish K; Reuter, Victor E; Solit, David B; Al‐Ahmadie, Hikmat A
- Abstract
We read with great interest the invited commentary by Akgul I et al i [1] on our report on the genomic landscape of urothelial papilloma (UP) and inverted urothelial papilloma (IUP) published in a recent issue of I The Journal of Pathology i [2]. Unlike UC, IUP and UP have low tumor mutational burden and do not exhibit a predominant APOBEC mutation signature. Furthermore, oncogenic alterations in I HRAS i and I KRAS i were present in nearly all cases of IUP and UP, whereas alterations common to UC, including mutations in I FGFR3, TP53 i , chromatin-modifying genes and the I TERT i promoter, were rarely observed.
- Subjects
TRANSITIONAL cell carcinoma; PAPILLOMA; BENIGN tumors; PATHOLOGY; BLADDER cancer; MOLECULAR oncology
- Publication
Journal of Pathology, 2020, Vol 250, Issue 4, p464
- ISSN
0022-3417
- Publication type
Article
- DOI
10.1002/path.5390