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- Title
CD8 Cell Noncytotoxic Antiviral Activity in Human Immunodeficiency Virus-Infected and -Uninfected Children.
- Authors
Levy, Jay A.; Hsueh, Frank; Blackbourn, David J.; Wara, Diane; Weintrub, Peggy S.
- Abstract
CD8 cells from human immunodeficiency virus (HIV)-infected adults and children can show cytotoxic as well as noncytotoxic activity against viral replication. The noncytotoxic anti-HIV response, measured by suppression of acute viral infection of CD4 cells, has also been observed in uninfected adults who have a history of exposure to HIV. This CD8 cell antiviral activity was found to be detectable as well in ∼50% of uninfected children born of infected mothers. The findings could reflect a protective response of the children to HIV after being exposed to the virus.
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 2, p470
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/517378