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- Title
Interleukin (IL)-6 and IL-8 in Children with Febrile Urinary Tract Infection and Asymptomatic Bacteriuria.
- Authors
Benson, Mikael; Jodal, Ulf; Agace, William; Hellström, Mikael; Mårild, Staffan; Rosberg, Sten; Sjöström, Michael; Wettergren, Björn; Jönsson, Susanne; Svanborg, Catharina
- Abstract
Urine and serum interleukin (IL)-6 and IL-8responseswere higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemolysin). Multivariate modeling showed that urine IL-6 responseswere higher in girls than boys, increased with age, and were positively associated with CRP, ESR, serum IL-6, and urine leukocyte counts. The urine IL-8 response was not influenced by age, but it was influenced by P fimbriae and was associated with ESR, CRP, urine leukocytes, and female sex. The results show that cytokine responses to urinary tract infection vary with the severity of infection and that cytokine activation is influenced by a variety of host and bacterial variables.
- Publication
Journal of Infectious Diseases, 1996, Vol 174, Issue 5, p1080
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/174.5.1080