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- Title
Serologic and Genetic Identification of Peromyscus maniculatus as the Primary Rodent Reservoir for a New Hantavirus in the Southwestern United States.
- Authors
Childs, James E.; Ksiazek, Thomas G.; Spiropoulou, Christina F.; Krebs, John W.; Morzunov, Sergey; Maupin, Gary O.; Gage, Kenneth L.; Rollin, Pierre E.; Sarisky, John; Enscore, Russell E.; Frey, Jennifer K.; Peters, C. J.; Nichol, Stuart T.
- Abstract
An outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was etiologically linked to a newly recognized hantavirus. Knowledge that hantaviruses are maintained in rodent reservoirs stimulated a field and laboratory investigation of 1696 small mammals of 31 species. The most commonly captured rodent, the deer mouse (Peromyscus maniculatus), had the highest antibody prevalence (30%) to four hantavirus antigens. Antibody also was detected in 10 other species of rodent and in 1 species of rabbit. Reverse transcriptase-polymerase chain reaction (RT-PCR) products of hantavirus from rodent tissues were indistinguishable from those from human HPS patients. More than 96% of the seropositive P. maniculatus were positive by RT-PCR, suggesting chronic infection. Antibody prevalences were similar among P. maniculatus trapped from Arizona (33%), New Mexico (29%), and Colorado (29%). The numeric dominance of P. maniculatus, the high prevalence of antibody, and the RT-PCR findings implicate this species as the primary rodent reservoir for a new hantavirus in the southwestern United States.
- Publication
Journal of Infectious Diseases, 1994, Vol 169, Issue 6, p1271
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/169.6.1271