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- Title
Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia.
- Authors
Kwon, Jae-Hyun; Kim, Young-Han; Kwon, Ja-Young; Park, Yong-Won
- Abstract
Background: We determined serum endogenous secretory receptor of advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) concentrations and the esRAGE/sRAGE ratio in normal pregnancy and preeclampsia because esRAGE and sRAGE have been negatively linked to components of metabolic syndromes and pathologic pregnancy including preeclampsia. Method: Eighty-seven normal pregnant women and 28 with preeclampsia were recruited. Serum sRAGE and esRAGE levels were measured by enzyme-linked immunosorbent assay. Results: There were significant differences in esRAGE concentration and esRAGE/sRAGE ratio between 1st and 3rd trimester in normal pregnancy (P =0.007 and P=0.003). Serum esRAGE concentrations and esRAGE/sRAGE ratio in patients with preeclampsia significantly increased compared to controls (P =0.005 and P<0.001). Conclusions: Maternal serum esRAGE concentration and esRAGE/sRAGE ratio (1) gradually decrease with gestational age in normal pregnancy; and (2) are higher in patients with preeclampsia than healthy pregnant controls, significantly. Serum esRAGE and esRAGE/sRAGE ratio might be associated with preeclampsia.
- Subjects
KOREA; PREECLAMPSIA diagnosis; ACADEMIC medical centers; ANALYSIS of variance; CELL receptors; STATISTICAL correlation; ENZYME-linked immunosorbent assay; STATISTICS; T-test (Statistics); U-statistics; DATA analysis; CASE-control method; DATA analysis software; BLOOD
- Publication
Journal of Perinatal Medicine, 2011, Vol 39, Issue 5, p507
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/JPM.2011.055