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- Title
Optimization of the radiosynthesis of [<sup>18</sup>F]MEFWAY for imaging brain serotonin 1A receptors by using the GE TracerLab FX<sub>FN-Pro</sub> module.
- Authors
Choi, Jae Yong; Kim, Chul Hoon; Ryu, Young Hoon; Seo, Young Beom; Truong, Phong; Kim, Eun Jung; Choi, Tae Hyun; Kang, JeeHae; Lee, Minkyung; Kim, Dong Goo; Lee, Jong Doo; Jeon, Tae Joo
- Abstract
The aim of this study was to develop a highly reliable radiofluorination method for the preparation of N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}- N-(2-pyridyl)- N-(4-18F-fluoromethylcyclohexane)carboxamide ([18F]Mefway) by using a fully automated system. The optimal condition is composed of two parts. The extraction system of the trapped F-18 in the anion exchange resin (i.e., quaternary methylamine cartridge) is a complex of Kryptofix 2.2.2. (K222, 4 mg/0.9 mL methanol) and K2CO3 (1 mg/0.1 mL H2O). After removing the solvents, the trans-tosylated Mefway precursor (1 mg/0.5 mL acetonitrile) was reacted with dried K222-K[18F] at 100°C for 5 min. After purification and formulation, [18F]Mefway was obtained with 38 ± 2.4% (decay corrected, n = 34) radiochemical yield, a total synthesis time of 52 ± 3.4 min, specific activity was 120.6 ± 8.7 GBq/µmol at the end of synthesis and a radiochemical purity of 99%. According to the quality control tests, formulated [18F]Mefway is suitable to apply parenteral clinical application.
- Subjects
SEROTONIN; NEUROTRANSMITTERS; POSITRON emission tomography; DIAGNOSTIC imaging; FLUORINATION
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2013, Vol 56, Issue 12, p589
- ISSN
0362-4803
- Publication type
Article
- DOI
10.1002/jlcr.3067