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- Title
High-Dose Metoclopramide and Dexamethasone as an Antiemetic in Chemotherapy of Breast Cancer.
- Authors
Gez, Eliahu; Goodman, Susan; Isacson, Rut; Gerra, Cilia; Sulkes, Aaron
- Abstract
Twenty-six patients with breast carcinoma who experienced severe emesis due to chemotherapy were evaluated for the antiemetic efficacy of high-dose metoclopramide (HD-MCP) and dexamethasone (DXM). Most of the patients received the CMF (cyclophosphamide, methotrexate and 5-fluorouracil) combination chemotherapy. The MCP and DXM dosage were: 2 × 2 mg/kg and 2 × 0.2 mg/kg, respectively. In 41 % of eighty evaluable courses, nausea and vomiting were eliminated altogether. The common side effects were: drowsiness, restlessness and diarrhea. HD-MCP and DXM are recommended in modified dose for preventing CMF chemotherapy induced emesis. Copyright © 1986 S. Karger AG, Basel
- Publication
Oncology, 1986, Vol 43, Issue 3, p173
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000226358