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- Title
Synthesis and Antimicrobial and Antituberculosis Activity of the First Conjugates of the Diterpenoid Isosteviol and D-Arabinofuranose.
- Authors
Sharipova, R. R.; Andreeva, O. V.; Garifullin, B. F.; Strobykina, I. Yu.; Strobykina, A. S.; Voloshina, A. D.; Kataev, V. E.; Kravchenko, M. A.
- Abstract
Previously unknown conjugates of the diterpenoid isosteviol <bold>1</bold> and 1-O-methyl-2,3-di-O-acetyl-β-Darabinofuranoside in which the terpenoid and carbohydrate molecules were linked through polymethylene spacers of various lengths were synthesized. Isosteviol <bold>1</bold> and its conjugate <bold>10</bold> exhibited high bacteriostatic activity selectively against Staphylococcus aureus ATCC 209p. Conjugates <bold>9</bold>-<bold>11</bold> inhibited growth of Mycobacterium tuberculosis H37Rv at the level of the antituberculosis drug pyrazinamide. Removal of the acetyl protection from conjugate <bold>9</bold> increased the antituberculosis activity by eight times.
- Subjects
STEVIOL; ARABINOSE; ANTI-infective agents; ANTIBACTERIAL agents; ANTINEOPLASTIC agents
- Publication
Chemistry of Natural Compounds, 2018, Vol 54, Issue 1, p92
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-018-2267-5