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- Title
THE ROLE OF ERAD PATHWAY ON INSULIN SECRETION IN PANCREATIC β-CELL.
- Authors
ALEXANDRU, PETRUTA R.; CHIRITOIU, GABRIELA N.; LIXANDRU, DANIELA; IONESCU-TARGOVISTE, CONSTANTIN; PETRESCU, STEFANA M.
- Abstract
Pancreatic β-cells secrete insulin in response to high blood glucose levels. Type I diabetes occurs when the body fails to produce insulin and the people must take artificial insulin. Type 2 diabetes is the most common type of diabetes and in this case the cells in the body do not respond to insulin and insulin resistance takes place gradually. The present study examined the role of Endoplasmic-reticulum-associated protein degradation (ERAD) on insulin secretion in pancreatic beta cells and diabetic rat model. We demonstrate that overexpression of some ER-stress induced proteins that targets misfolded glycoproteins for ER-associated degradation in INS-1 cells increased preproinsulin mRNA, facilitates proinsulin transport to the secretory vesicles, conversion and secretion of mature insulin. Such effects were also observed in human pancreatic islets and streptozotocin diabetic rats. Our findings identify a role of ERAD pathway as potential target for the treatment of diabetes.
- Subjects
PANCREATIC secretions; PANCREATIC beta cells; INSULIN; STREPTOZOTOCIN; TYPE 2 diabetes; SECRETORY granules; ENDOPLASMIC reticulum; PROINSULIN
- Publication
Journal of Experimental & Molecular Biology, 2019, Vol 20, Issue 3, p64
- ISSN
2601-6974
- Publication type
Article