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- Title
Overall Survival Time And Prognostic Factors Of Mortality In Triple Negative Breast Cancer In Malaysia.
- Authors
Harun, Husna Haji; Mohamad, Ikhwan Sani; Wan Mokhter, Wan Mokhzani; Yahya, Maya Mazuwin; Wan Zain, Wan Zainira; Isa, Junaidi Awang; Ab Hadi, Imi Sairi
- Abstract
Background: Breast cancer remains the leading health concern among females in Malaysia. This study aims to compare the survival time between triple negative breast cancer (TNBC) and non-triple negative breast cancer (NTNBC),its proportion and prognostic factor of mortality among TNBC patient. Methods: This is a retrospective cohort study of patients with breast cancer treated at Hospital Raja Perempuan Zainab II (HRPZ II) from 1st January 2007 till 31st December 2013. Kaplan Meier survival analysis was used to compare median survival time between TNBC and NTNBC. Univariate and multivariate analysis were performed to determine prognostic factor of mortality for TNBC including: age, tumor size, lymph node ratio, histological tumor grade, lymphovascular invasion and type of treatment. Results: Out of one hundred fifty one (151) breast cancer patients, thirty two (32) of them were TNBC. The proportion of TNBC and NTNBC incidences made up 21.2% and 78.8% respectively. Overall median survival time of TNBC and NTNBC patients cannot be determined as death occurred in less than 50% of patients (47.7%). However estimated mean and median survival time of TNBC were much lower than NTNBC, which were 29.7 months (95% CI: 21.41, 38.05) versus 34.3 months (95% CI: 28.18, 40.46) and 23.0 months (95% CI: 16.28, 29.78) versus 30.8 months (95% CI: 21.43, 40.14) respectively. There were no significant prognostic factors among TNBC patients whereby the univariate analysis showed that tumor size and lymph node ratio were the significant factors of mortality among all breast cancer patients. Conclusion: Our study concluded that regardless of breast cancer subtypes, the factors that affect overall median survival time were tumor size and lymph node ratio.
- Subjects
MALAYSIA; TRIPLE-negative breast cancer; BREAST cancer prognosis; CANCER-related mortality; DISEASE incidence
- Publication
Surgical Chronicles, 2020, Vol 25, Issue 4, p355
- ISSN
1108-5002
- Publication type
Article