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- Title
Hepatitis C virus and risk of non-Hodgkin lymphoma in British Columbia, Canada.
- Authors
Spinelli, John J.; Lai, Agnes S.; Krajden, Mel; Andonov, Anton; Gascoyne, Randy D.; Connors, Joseph M.; Brooks-Wilson, Angela R.; Gallagher, Richard P.
- Abstract
We investigated Hepatitis C virus (HCV) seropositivity and the risk of non-Hodgkin lymphoma (NHL) in a population-based case-control study in British Columbia, Canada. Cases were aged 20-79, diagnosed between March 2000 and February 2004, and resident in greater Vancouver or Victoria. Cases with HIV or a prior transplant were excluded. Controls were chosen from the Client Registry of the British Columbia (BC) Ministry of Health, and were age/sex/region frequency matched to cases. Antibodies for HCV were measured in 795 cases and 697 control subjects. HCV seropositivity was 2.4% in cases and 0.7% in controls [odds ratio (OR) = 2.6, 95% confidence interval (CI) = 0.9-7.4]. A significantly elevated risk was observed for B-cell lymphoma (OR = 2.9, 95%CI = 1.0-8.6). The highest risks were associated with diffuse large B-cell lymphoma (OR = 7.3, 95%CI = 2.1-25.0) and marginal zone lymphoma (OR = 6.1, 95%CI = 1.1-33.9). Our results provide further evidence that HCV infection contributes to NHL risk. © 2007 Wiley-Liss, Inc.
- Publication
International Journal of Cancer, 2008, Vol 122, Issue 3, p630
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.23105