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- Title
Reward-related decision-making in pediatric major depressive disorder: an fMRI study.
- Authors
Forbes, Erika E.; Christopher May, J.; Siegle, Greg J.; Ladouceur, Cecile D.; Ryan, Neal D.; Carter, Cameron S.; Birmaher, Boris; Axelson, David A.; Dahl, Ronald E.
- Abstract
Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems. Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9–17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder. Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas. Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing.
- Subjects
MAGNETIC resonance imaging of the brain; REWARD (Psychology); DECISION making; AFFECTIVE disorders; DEPRESSION in adolescence; MOTIVATION (Psychology); ANXIETY disorders; PATIENTS
- Publication
Journal of Child Psychology, 2006, Vol 47, Issue 10, p1031
- ISSN
0021-9630
- Publication type
Article
- DOI
10.1111/j.1469-7610.2006.01673.x