We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence.
- Authors
Kyoji Okita; Mandelkern, Mark A.; London, Edythe D.
- Abstract
Background: Cigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence. Smokers also exhibit lower dopamine D2/3 receptor availability in the dorsal striatum than nonsmokers. Negative correlations of striatal dopamine D2/3 receptor availability with smoking exposure and nicotine dependence, therefore, might be expected but have not been tested. Methods: Twenty smokers had positron emission tomography scans with [18F]fallypride to measure dopamine D2/3 receptor availability in ventral and dorsal regions of the striatum and provided self-report measures of recent and lifetime smoking and of nicotine dependence. Results: As reported before, lifetime smoking was correlated with nicotine dependence. New findings were that ventral striatal dopamine D2/3 receptor availability was negatively correlated with recent and lifetime smoking and also with nicotine dependence. Conclusion: The results suggest an effect of smoking on ventral striatal D2/3 dopamine receptors that may contribute to nicotine dependence.
- Subjects
DOPAMINE receptors; NICOTINE addiction; SMOKING; POSITRON emission tomography; SELF-evaluation
- Publication
International Journal of Neuropsychopharmacology, 2016, Vol 19, Issue 11, p1
- ISSN
1461-1457
- Publication type
Article
- DOI
10.1093/ijnp/pyw074