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- Title
Androgen Receptor Expression in Thai Breast Cancer Patients.
- Authors
Suthat Chottanapund; Van Duursen, M. B. M.; Kumpol Ratchaworapong; Panida Navasumrit; Mathuros Ruchirawat; Den Berg, Martin Van
- Abstract
The aim of this study was to investigate prevalence and related factors of androgen receptor (AR) expression in Thai breast cancer patients. A descriptive study was done in 95 patients, who were admitted to Charoenkrung Pracharak Hospital, Bangkok (2011-2013). Statistical relationships were examined between AR protein expression, tumor status, and patient characteristics. Compared with those from Western countries, ethnic Thai patients were younger at age of diagnosis and had a higher proliferative index (high Ki-67 expression), which indicates unfavorable prognosis. In addition, 91% of the Thai breast tumors that were positive for any of the following receptors, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) also expressed the AR protein, while in triple negative breast tumors only 33% were AR positive. ER and PR expression was positively related with AR expression, while AR expression was inversely correlated to Ki-67 expression. AR status was strongly correlated with ER and PR status in Thai patients. There is an inverse relationship between Ki-67 and AR, which suggests that AR may be a prognostic factor for breast cancer.
- Subjects
ANDROGEN receptors; BREAST cancer patients; PROGESTERONE receptors; ESTROGEN receptors; THAI social conditions; PHYSIOLOGY
- Publication
Medical Sciences, 2016, Vol 4, Issue 3, p15
- ISSN
2076-3271
- Publication type
Article
- DOI
10.3390/medsci4030015