We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The natural cytotoxic receptors (NKp30, NKp44 and NKp46) gene expression in Coeliac disease patients.
- Authors
Khodapanah, Maryam; Asri, Nastaran; Rostami-Nejad, Mohammad; Hashemi, Mehrdad; Aahdaei, Hamid Asadzadeh
- Abstract
Objectives: Defects in the expression of natural killer (NK) cells activating receptors (like NKp30, NKp44, and NKp46) impair the ability of NK cells to kill virus-infected cells and are associated with amplified local inflammation. This study aimed to evaluate the expression of these receptors in coeliac disease (CD) patients relative to controls. Methods: We analysed the NKp30, NKp46 and NKp44 genes expression in intestinal biopsy specimens of 40 confirmed coeliac disease patients and 40 controls using the real-time PCR method. Results: The NKp30 mRNA expression in coeliac disease patients was significantly lower than in controls (p=0.01) with a significant inverse correlation with the patient's weight loss symptom (p=0.0173). The NKp44 mRNA expression was extremely higher in coeliac disease patients than in controls (p=0.02). The mRNA expression of NKp46 did not differ between patients and controls (p=0.3). The expression levels of these receptors did not show any significant difference between Marsh II and Marsh III groups of patients and controls (p>0.05). Conclusion: Further studies are needed to elucidate the predominant NKp30 isoform and possible SNP role in controlling its expression in coeliac disease which leads to designing innovative targeted therapy for coeliac disease patients.
- Subjects
RESEARCH; CELL receptors; CASE-control method; KILLER cells; CELIAC disease; GENE expression; COMPARATIVE studies; DESCRIPTIVE statistics; GENE expression profiling; WEIGHT loss; MESSENGER RNA; COLLECTION &; preservation of biological specimens; INTESTINAL mucosa; POLYMERASE chain reaction; STATISTICAL correlation; DATA analysis software; SYMPTOMS
- Publication
New Zealand Journal of Medical Laboratory Science, 2023, Vol 77, Issue 2, p65
- ISSN
1171-0195
- Publication type
Article