We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes.
- Authors
Dao-Huy, Toan; Latkolik, Simone; Bräuer, Julia; Pfeil, Andreas; Stuppner, Hermann; Schnürch, Michael; Dirsch, Verena M.; Mihovilovic, Marko D.
- Abstract
A series of 2-arylbenzofurans and 2-arylbenzothiophenes was synthesized carrying three different side chains in position five. The synthesized compounds were tested for NF-κB inhibition to establish a structure activity relationship. It was found that both, the side chain in position five and the substitution pattern of the aryl moiety in position two have a significant influence on the inhibitory activity.
- Subjects
STRUCTURE-activity relationships; MOLECULAR biology; MOIETIES (Chemistry); BENZOFURANS
- Publication
Biomolecules (2218-273X), 2020, Vol 10, Issue 8, p1131
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom10081131