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- Title
Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura.
- Authors
Rico-Portillo, Ana Paola; Cerrillos-Gutierrez, José Ignacio; Andrade-Sierra, Jorge; Gutiérrez-Govea, Alfredo; Rojas-Campos, Enrique; Mendoza-Cerpa, Claudia Alejandra; Gómez-Navarro, Benjamín
- Abstract
A 47-year-old male was diagnosed with chronic kidney disease (CKD) in 2011; idiopathic thrombocytopenic purpura (ITP) was also diagnosed in 2011 refractory to medical treatment and finally treated with splenectomy (2017) without relapses since that date, 5 blood transfusions, and 4 platelet apheresis in 2017. Renal transplant from a living related donor (brother), ABO compatible, crossmatch were negative, sharing 1 haplotype. Donor-specific anti-HLA antibody was negative. Graft function was stable until the 5th day and graft biopsy on the 6th day; thrombotic microangiopathy (TMA), C4D negative and inflammatory infiltration of polymorphonuclear leukocytes inside peritubular capillary, and anti-MICA antibodies were positive. The treatment used were plasmapheresis, intravenous immunoglobulin, and rituximab. Serum creatinine began to decrease since the 14th day, and by day 33, post-RT graft function was restored.
- Subjects
GRAFT rejection; KIDNEY transplantation; THERAPEUTICS; CHRONIC kidney failure; BLOOD transfusion
- Publication
Case Reports in Transplantation, 2021, p1
- ISSN
2090-6943
- Publication type
Article
- DOI
10.1155/2021/9933354