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- Title
Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.
- Authors
Jeha, S.; Pei, D.; Raimondi, S. C.; Onciu, M.; Campana, D.; Cheng, C.; Sandlund, J. T.; Ribeiro, R. C.; Rubnitz, J. E.; Howard, S. C.; Downing, J. R.; Evans, W. E.; Relling, M. V.; Pui, C.-H.
- Abstract
To evaluate the impact of contemporary therapy on the clinical outcome of children with pre-B acute lymphoblastic leukemia (ALL) and the t(1;19)/TCF3/PBX1, we analyzed 735 patients with B-cell precursor ALL treated in four successive protocols at St Jude Children's Research Hospital. The 41 patients with the t(1;19) had a comparable event-free survival to that of the 694 patients with other B-cell precursor ALL (P=0.63; 84.2+/-7.1% (s.e.) vs 84.0+/-1.8% at 5 years). However, patients with the t(1;19) had a lower cumulative incidence of any hematological relapse (P=0.06; 0 vs 8.3+/-1.2% at 5 years) but a significantly higher incidence of central nervous system (CNS) relapse (P<0.001; 9.0+/-5.1% vs 1.0+/-0.4% at 5 years). In a multivariate analysis, the t(1;19) was an independent risk factor for isolated CNS relapse. These data suggest that with contemporary treatment, patients with the t(1;19) and TCF3/PBX1 fusion have a favorable overall outcome but increased risk of CNS relapse.
- Subjects
LYMPHOBLASTIC leukemia; JUVENILE diseases; CANCER relapse; CENTRAL nervous system; LEUKEMIA; ANTINEOPLASTIC agents; CANCER invasiveness; CHROMOSOME abnormalities; CHROMOSOMES; CLINICAL trials; COMBINED modality therapy; COMPARATIVE studies; SPINAL injections; RESEARCH methodology; MEDICAL cooperation; PROGNOSIS; PROTEINS; RADIOTHERAPY; RESEARCH; RESEARCH funding; RISK assessment; EVALUATION research; RELATIVE medical risk; TREATMENT effectiveness; DISEASE incidence; PROPORTIONAL hazards models; GENOTYPES; PREVENTION
- Publication
Leukemia (08876924), 2009, Vol 23, Issue 8, p1406
- ISSN
0887-6924
- Publication type
journal article
- DOI
10.1038/leu.2009.42