We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Protean clinical manifestations in children with leukemias containing MLL-AF10 fusion.
- Authors
Gore, L; Ess, J; Bitter, M A; McGavran, L; Meltesen, L; Wei, Q; Hunger, S P
- Abstract
Translocations involving the MLL gene on chromosome 11q23 occur in 5-10% of human leukemias, and involve fusion with more than 30 different partner genes. The MLL-AF10 fusion produced by the t(10;11)(p12;q23) or ins(10;11)(p12;q23q13) occurs in a small percentage of acute leukemias, most commonly acute myelogenous leukemia (AML) of the M5 FAB subtype. We report two cases of AML (M5a and M0) and one case of acute lymphoblastic leukemia containing MLL-AF10 fusion. Each case had varied clinical characteristics, despite expressing similar MLL-AF10 fusion transcripts. Including the three cases described in this report, we identified a total of 38 cases of leukemia with MLL-AF10 fusion. Approximately one-third of these are not M5 AML. Taken together, these findings emphasize that while the sentinel molecular event may be identical in a disease, the clinical presentation and outcome can vary widely.
- Subjects
ACUTE leukemia; GENES; CHROMOSOMAL translocation
- Publication
Leukemia (08876924), 2000, Vol 14, Issue 12, p2070
- ISSN
0887-6924
- Publication type
journal article
- DOI
10.1038/sj.leu.2401966