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- Title
Pilot Phase II Trial of Bevacizumab Monotherapy in Nonmetastatic Castrate-Resistant Prostate Cancer.
- Authors
Ogita, Shin; Tejwani, Sheela; Heilbrun, Lance; Fontana, Joseph; Heath, Elisabeth; Freeman, Stacy; Smith, Daryn; Baranowski, Karen; Vaishampayan, Ulka
- Abstract
Introduction/Background. Nonmetastatic castrate resistant prostate cancer (CRPC) is a challenging disease state. The objective of this study was to evaluate the efficacy and tolerability of bevacizumab in nonmetastatic CRPC patients. Patients. Patients with prostate cancer who developed PSA recurrence after local therapy were included if they had absence of bone or visceral metastases and PSA progression despite androgen deprivation therapy. Methods. Bevacizumab 10 mg/kg intravenously was administered every 14 days until PSA progression, development of metastasis, or unacceptable toxicity. Results. 15 patients were enrolled and treated with bevacizumab for a median duration of 3.1 months. Median baseline PSA was 27 ng/mL, and seven patients had Gleason Score =8. Five patients had declined in PSA during the treatment. Median PSA doubling time was prolonged from 4.7 months pretreatment to 6.5 months. Median time to PSA progression and new metastasis were 2.8 and 7.9 months, respectively. There were three grade 3 adverse events (one proteinuria and two hypertension) and one pulmonary embolism. There was no treatment-related mortality. Conclusion. Bevacizumab therapy had minimal impact on the disease course of nonmetastatic CRPC, and investigation of novel strategies is needed.
- Subjects
MICHIGAN; CLINICAL trials; CONFIDENCE intervals; HEALTH outcome assessment; PROSTATE tumors; RESEARCH funding; PILOT projects; TREATMENT effectiveness; BEVACIZUMAB; DESCRIPTIVE statistics; KAPLAN-Meier estimator; PATHOLOGIC neovascularization; PHARMACODYNAMICS
- Publication
ISRN Oncology, 2012, p1
- ISSN
2090-5661
- Publication type
Article
- DOI
10.5402/2012/242850