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- Title
Trace element abnormalities in chronic uremia.
- Authors
Smythe, W. Rodman; Alfrey, Allen C.; Craswell, Peter W.; Crouch, Cynthia A.; Ibels, Lloyd S.; Kubo, Hideo; Nunnelley, Lewis L.; Rudolph, Harvey; Smythe, W R; Alfrey, A C; Craswell, P W; Crouch, C A; Ibels, L S; Kubo, H; Nunnelley, L L; Rudolph, H
- Abstract
We studied the elemental composition of autopsy tissue samples to characterize the trace element changes induced in various human tissues by uremia. Samples from the United States and Australia, including those from 120 uremic patients who had been on dialysis, 29 uremic patients who had not been on dialysis, and 64 control subjects, were analyzed by x-ray fluorescence. Tissues analyzed were aorta, bone, brain, heart, kidney, liver, lung, muscle, and spleen; elements measured included potassium, calcium, iron, copper, zinc, selenium, bromine, rubidium, strontium, molybdenum, cadmium, tin, and uranium. Uremic abnormalities that were statistically very significant were found, including increases of calcium, strontium, molybdenum, cadmium, and tin and decreases of potassium and rubidium. The distribution of iron, copper, and zinc are altered. We conclude that these abnormalities are primarily the result of the uremia and that, generally, they are neither greatly moderated nor exacerbated by the dialysis procedure.
- Subjects
AUSTRALIA; UNITED States; UREMIA; TISSUES; AUTOPSY; TRACE element analysis; CHRONIC diseases; COMPARATIVE studies; KIDNEYS; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SPLEEN; X-ray spectroscopy; EVALUATION research; BODY burden
- Publication
Annals of Internal Medicine, 1982, Vol 96, Issue 3, p302
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-96-3-302