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- Title
Reduced serum levels of 1 alpha,25-dihydroxyvitamin D during long-term total parenteral nutrition.
- Authors
Klein, Gordon L.; Horst, Ronald L.; Norman, Anthony W.; Ament, Marvin E.; Slatopolsky, Eduardo; Coburn, Jack W.; Klein, G L; Horst, R L; Norman, A W; Ament, M E; Slatopolsky, E; Coburn, J W
- Abstract
Painful bone disease, characterized by patchy osteomalacia and inactive bone, can develop in patients treated with total parenteral nutrition for more than 3 months. Serum levels of 1 alpha,25-dihydroxyvitamin D (1 alpha, 25(OH)2D), 24,25-dihydroxyvitamin D and 25-hydroxyvitamin D were measured in seven adults and five children treated with parenteral nutrition for 9 to 60 months. Serum levels of 1 alpha, 25(OH)2D were markedly reduced, while levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D were normal. Serum calcium and phosphorus levels were normal or slightly increased, and immunoreactive parathyroid hormone levels were normal or low. Renal function was normal or minimally reduced. Skeletal symptoms disappeared and serum 1 alpha, 25(OH)2D levels rose to normal in one patient when nutrient infusions were discontinued for 6 weeks. Removal of calcium from the nutrient solution for 2 to 4 days was associated with no change in serum 1 alpha, 25(OH)2D in two patients. The cause of the reduction in serum levels of 1 alpha, 25(OH)2D and its role in the pathogenesis of bone disease in these patients remain uncertain.
- Subjects
VITAMIN D; TOTAL parenteral feeding; SERUM; CALCIUM; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; OSTEOMALACIA; PARATHYROID hormone; PARENTERAL feeding; PHOSPHORUS; RESEARCH; TIME; EVALUATION research; CALCITRIOL
- Publication
Annals of Internal Medicine, 1981, Vol 94, Issue 5, p638
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-94-5-638