We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A standardized clinical database for research in Chagas disease: The NHEPACHA network.
- Authors
González Martínez, Adriana; Losada-Galván, Irene; Gabaldón-Figueira, Juan Carlos; Martínez-Peinado, Nieves; Saraiva, Roberto Magalhães; Fernández, Marisa Liliana; Ramsey, Janine M.; Noya-González, Oscar; Alarcón de Noya, Belkisyole; Schijman, Alejandro Gabriel; Berón, Soledad; Abril, Marcelo; Gascón, Joaquim; Sosa-Estani, Sergio; Pinazo, María Jesús; Alonso-Padilla, Julio; Hasslocher-Moreno, Alejandro Marcel
- Abstract
The NHEPACHA Iberoamerican Network, founded on the initiative of a group of researchers from Latin American countries and Spain, aims to establish a research framework for Chagas disease that encompasses diagnosis and treatment. For this purpose, the network has created a questionnaire to gather relevant data on epidemiological, clinical, diagnostic, and therapeutic aspects of the disease. This questionnaire was developed based on a consensus of expert members of the network, with the intention of collecting high-quality standardized data, which can be used interchangeably by the different research centers that make up the NHEPACHA network. Furthermore, the network intends to offer a clinical protocol that can be embraced by other researchers, facilitating comparability among published studies, as well as the development of therapeutic response and progression markers. Author summary: In this work, we present a new clinical questionnaire for the standardized evaluation and collection of clinical data from patients with acute or chronic Trypanosoma cruzi infection, as well as a uniformed database to collect it. The questionnaire has been produced after consensus from clinical experts belonging to the NHEPACHA network, a coalition of clinical research institutions in Latin America and Spain. This tool will facilitate the collection and sharing of high-quality clinical and paraclinical data useful to annotate sample collections, and allow clinically meaningful comparisons between different cohorts.
- Subjects
CHAGAS' disease; MEDICAL research; RESEARCH personnel; MEDICAL protocols; TRYPANOSOMA cruzi
- Publication
PLoS Neglected Tropical Diseases, 2024, Vol 18, Issue 8, p1
- ISSN
1935-2727
- Publication type
Article
- DOI
10.1371/journal.pntd.0012364