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- Title
Uric acid relates to dopamine transporter availability in Parkinson's disease.
- Authors
Moccia, M.; Pappatà, S.; Erro, R.; Picillo, M.; Vitale, C.; Amboni, M.; Longo, K.; Palladino, R.; Barone, P.; Pellecchia, Maria Teresa
- Abstract
Background Diagnosing Parkinson's disease ( PD) and tracking its progression may require the combination of reliable biomarkers. Among them, both serum uric acid ( UA) and dopamine transporter ( Da T) binding deserve more investigations. Aims of the study We aimed to investigate the relationship between serum UA levels and Da T availability in newly diagnosed, drug-naïve PD patients, by means of semiquantitative [(123) I] FP- CIT- SPECT. Methods We recruited 52 newly diagnosed, drug-naïve PD patients, and performed serum UA dosage and [(123) I] FP- CIT- SPECT. Results Pearson's correlation analysis showed that UA levels were significantly higher in patients with higher averaged, ipsilateral and contralateral Da T binding in caudate, putamen, and striatum. Conclusions We showed, for the first time, by regional semiquantitative analysis of Da T binding in PD patients that UA levels significantly correlates with the severity of dopaminergic impairment in caudate, putamen, and striatum. This study broadens our knowledge on the importance of UA as a biomarker of PD.
- Subjects
URIC acid; DOPAMINE; BIOAVAILABILITY; PARKINSON'S disease; BIOLOGICAL transport; BIOMARKERS; BLOOD serum analysis
- Publication
Acta Neurologica Scandinavica, 2015, Vol 131, Issue 2, p127
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1111/ane.12295