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- Title
Lumbar infusion test in normal pressure hydrocephalus.
- Authors
Kahlon, B.; Sundbärg, G.; Rehncrona, S.
- Abstract
Kahlon B, Sundbärg G, Rehncrona S. Lumbar infusion test in normal pressure hydrocephalus.Acta Neurol Scand 2005: 111: 379–384.© Blackwell Munksgaard 2005.To compare potential clinical value of plateau pressure (Ppl), resistance to outflow (Rout), pulse-pressure amplitude (PplA) and rate of pressure increase (v P), taken from the constant rate lumbar infusion test (LIT), as predictors for the outcome of shunt surgery.Recordings from preoperative LIT in 55 patients were scrutinized for the values ofPpl,PplA,v P andRout. Gait, memory, spatial capacity and reaction ability were tested before and 6 months after shunt surgery.Forty-three (78%) of the patients improved. There were no statistically significant differences inPpl,Rout,PplA orv P between improved and not improved patients. Five patients withPpl below 22 mmHg (the cut off level) improved after shunting, while 16 and eight patients withRout below the cut off levels of 18 and 14 mmHg/ml/min improved.PplA correlated withPpl andRout (r = 0.74 and 0.63, respectively). In the group of patients with highPplA (≥20 mmHg) as many as 93% improved but a highPplA did not recruit more improved patients thanPpl orRout alone.v P orPplA does not add useful information toPpl for selecting patients with suspected NPH for surgery.Rout calculations from LIT does not provide advantage over using the steady-state plateau pressure for selecting patients for surgery and may increase the risk of missing patients who should benefit from surgery.
- Subjects
BRAIN diseases; HYDROCEPHALUS; SURGERY; DISEASES; MEMORY; PSYCHOLOGY
- Publication
Acta Neurologica Scandinavica, 2005, Vol 111, Issue 6, p379
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1111/j.1600-0404.2005.00417.x