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- Title
Endothelial glycocalyx degradation depends rather on inflammatory status than hemodynamic conditions.
- Authors
Jahangiri, Mohammad; Mercier, Nathalie; Toupance, Simon; Thomas, Arthur; Labas, Carlos; Regnault, Véronique; Benetos, Athanase; Lacolley, Patrick; Lagrange, Jeremy
- Abstract
Background and Objectives: Glycocalyx, a thin layer of carbohydrates covering endothelial cells, is important for interactions between blood components and the vascular wall. It is implicated in circulating cells adhesion, inflammation, and coagulation regulation and can be damaged in some diseases. The prevailing hypothesis is that hypertension is the primary factor involved in glycocalyx degradation. However, our preliminary data challenge this view and point to a more important role of inflammation. The objective of this study was to assess the respective roles of inflammation and hemodynamic on the endothelial glycocalyx degradation. Methods and Results: Plasma concentrations of syndecan-1, a glycocalyx degradation marker, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 were quantified by ELISA in 327 participants (62 ± 14 years). Subjects were categorized as atherosclerotic cardio-vascular diseases (ASCVD) patients or controls and performed all a blood pressure and pulse wave velocity assessment. Syndecan-1 was positively associated with circulating IL-6 (p < 0.001), IL-8 (p = 0.002), and IL-10 concentrations (p = 0.006) and with adhesion molecules ICAM-1 and VCAM-1 (p < 001). No relation was observed between syndecan-1 and hemodynamic parameters, thus confirming the major role of inflammatory status in the degradation of endothelial glycocalyx. Interestingly, subjects with higher plasma concentration of syndecan-1 (third tertile) displayed more clinical manifestation of atherosclerosis (65 vs 42%; p < 0.001) than those with lower concentration (first tertile). Conclusions: Endothelial glycocalyx degradation is rather associated with inflammatory status than hemodynamic parameters. Higher degradation of glycocalyx is associated with increased percentage of ASCVD suggesting a direct relation between glycocalyx degradation and increased risk of atherosclerotic diseases.
- Subjects
ENDOTHELIAL cells; INFLAMMATION; HEMODYNAMICS
- Publication
Artery Research, 2023, Vol 29, Issue 1, pS41
- ISSN
1872-9312
- Publication type
Article
- DOI
10.1007/s44200-022-00028-8