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- Title
Relationship between aortic and carotid stiffness with measures of adiposity in adolescents. The maciste study.
- Authors
Pucci, Giacomo; Martina, Mariella; Bianchini, Elisabetta; Gemignani, Vincenzo; D'Abbondanza, Marco; Curcio, Rosa; Battista, Francesca; Anastasio, Fabio; Vaudo, Gaetano
- Abstract
Background: We evaluated the differential association between arterial stiffness, taken at different arterial segments (aortic and carotid), with global and local measures of adiposity, accounting for BP as a mediator of the relationship between fat accumulation and increased arterial stiffness. Methods: 322 healthy Italian adolescents from the MACISTE Study (Metabolic and Cardiovascular Investigation at School, TErni), were evaluated. BMI, waist, hip and neck circumferences (NC) were taken as measures of adiposity. Laboratory measures of adiposity were also collected. Arterial stiffness was measured through carotid-femoral pulse wave velocity (applanation tonometry, SphygmoCor), and at the carotid level (Cardiovascular suite, Quipu, Italy). Results: Mean age 17 ± 1.4 years, 56% boys, 40 (12%) with overweight. All central and peripheral measures of BP were higher in overweight vs normoweight (all p < 0.01) excluding peripheral and central DBPs, which were lower in overweight. The aortic-to-brachial pulse pressure amplification was reduced in overweight vs normoweight (1.51 ± 0.13 vs 1.58 ± 0,13, p < 0.01). Carotid and aortic stiffness were positively correlated with anthropometric and laboratory measures of adiposity. After adjustment for MAP, only NC remained associated with carotid (β = 0.24, p < 0.01) and aortic stiffness (β = 0.16, p = 0.02). After adjustment for central PP, only carotid (β = 0.15, p = 0.04), but not aortic stiffness (β = 0.12, p = 0.07) was associated with NC. Conclusions: Arterial stiffness, when assessed at different levels of central arteries, showed site-specific associations with measures of body fat adiposity. NC was the only measure of adiposity to show a BP-independent association with carotid stiffness. Carotid stiffness is a promising marker of pressure-independent vascular damage promoted by overweight status.
- Subjects
OBESITY; TONOMETRY
- Publication
Artery Research, 2023, Vol 29, Issue 1, pS19
- ISSN
1872-9312
- Publication type
Article
- DOI
10.1007/s44200-022-00028-8