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Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.
Published in:
NPJ Parkinson's Disease, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41531-021-00203-9
By:
- Oliveira, Luis M. A.;
- Gasser, Thomas;
- Edwards, Robert;
- Zweckstetter, Markus;
- Melki, Ronald;
- Stefanis, Leonidas;
- Lashuel, Hilal A.;
- Sulzer, David;
- Vekrellis, Kostas;
- Halliday, Glenda M.;
- Tomlinson, Julianna J.;
- Schlossmacher, Michael;
- Jensen, Poul Henning;
- Schulze-Hentrich, Julia;
- Riess, Olaf;
- Hirst, Warren D.;
- El-Agnaf, Omar;
- Mollenhauer, Brit;
- Lansbury, Peter;
- Outeiro, Tiago F.
Publication type:
Article
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain.
Published in:
Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01131-8
By:
- Ferreira, Nelson;
- Gonçalves, Nádia Pereira;
- Jan, Asad;
- Jensen, Nanna Møller;
- van der Laan, Amelia;
- Mohseni, Simin;
- Vægter, Christian Bjerggaard;
- Jensen, Poul Henning
Publication type:
Article
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain.
Published in:
Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01131-8
By:
- Ferreira, Nelson;
- Gonçalves, Nádia Pereira;
- Jan, Asad;
- Jensen, Nanna Møller;
- van der Laan, Amelia;
- Mohseni, Simin;
- Vægter, Christian Bjerggaard;
- Jensen, Poul Henning
Publication type:
Article
Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-07706-2
By:
- Reimer, Lasse;
- Haikal, Caroline;
- Gram, Hjalte;
- Theologidis, Vasileios;
- Kovacs, Gergo;
- Ruesink, Harm;
- Baun, Andreas;
- Nielsen, Janni;
- Otzen, Daniel Erik;
- Li, Jia-Yi;
- Jensen, Poul Henning
Publication type:
Article
Alpha-Synuclein Strain Variability in Body-First and Brain-First Synucleinopathies.
Published in:
Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.907293
By:
- Just, Mie Kristine;
- Gram, Hjalte;
- Theologidis, Vasileios;
- Jensen, Poul Henning;
- Nilsson, K. Peter R.;
- Lindgren, Mikael;
- Knudsen, Karoline;
- Borghammer, Per;
- Van Den Berge, Nathalie
Publication type:
Article
Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats.
Published in:
2021
By:
- Berge, Nathalie Van Den;
- Ferreira, Nelson;
- Mikkelsen, Trine Werenberg;
- Alstrup, Aage Kristian Olsen;
- Tamgüney, Gültekin;
- Karlsson, Páll;
- Terkelsen, Astrid Juhl;
- Nyengaard, Jens Randel;
- Jensen, Poul Henning;
- Borghammer, Per;
- Van Den Berge, Nathalie
Publication type:
journal article
The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 15, p. 8338, doi. 10.3390/ijms22158338
By:
- Jan, Asad;
- Gonçalves, Nádia Pereira;
- Vaegter, Christian Bjerggaard;
- Jensen, Poul Henning;
- Ferreira, Nelson
Publication type:
Article
The expression of tubulin polymerization promoting protein TPPP/p25α is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress.
Published in:
Glia, 2008, v. 56, n. 16, p. 1736, doi. 10.1002/glia.20720
By:
- Goldbaum, Olaf;
- Jensen, Poul Henning;
- Richter-Landsberg, Christiane
Publication type:
Article
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers.
Published in:
Fluids & Barriers of the CNS, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12987-022-00334-y
By:
- Alam, Parvez;
- Holst, Mikkel R.;
- Lauritsen, Line;
- Nielsen, Janni;
- Nielsen, Simone S. E.;
- Jensen, Poul Henning;
- Brewer, Jonathan R.;
- Otzen, Daniel E.;
- Nielsen, Morten S.
Publication type:
Article
Expression of tissue transglutaminase in human bladder carcinoma.
Published in:
Journal of Pathology, 1997, v. 183, n. 4, p. 398, doi. 10.1002/(SICI)1096-9896(199712)183:4<398::AID-PATH947>3.0.CO;2-3
By:
- Hager, Henrik;
- Jensen, Poul Henning;
- Hamilton-Dutoit, Stephen;
- Nielsen, Morten S.;
- Birckbichler, Poul;
- Gliemann, Jørgen
Publication type:
Article
DEVELOPMENTAL REGULATION OF TISSUE TRANSGLUTAMINASE DURING HUMAN PLACENTATION AND EXPRESSION IN NEOPLASTIC TROPHOBLAST.
Published in:
Journal of Pathology, 1997, v. 181, n. 1, p. 106, doi. 10.1002/(SICI)1096-9896(199701)181:1<106::AID-PATH725>3.0.CO;2-K
By:
- HAGER, HENRIK;
- GLIEMANN, JØRGEN;
- HAMILTON-DUTOIT, STEPHEN;
- EBBESEN, PETER;
- KOPPELHUS, UFFE;
- HENNING JENSEN, POUL
Publication type:
Article
Monomeric α‐synuclein activates the plasma membrane calcium pump.
Published in:
EMBO Journal, 2023, v. 42, n. 23, p. 1, doi. 10.15252/embj.2022111122
By:
- Kowalski, Antoni;
- Betzer, Cristine;
- Larsen, Sigrid Thirup;
- Gregersen, Emil;
- Newcombe, Estella A;
- Bermejo, Montaña Caballero;
- Bendtsen, Viktor Wisniewski;
- Diemer, Jorin;
- Ernstsen, Christina V;
- Jain, Shweta;
- Bou, Alicia Espiña;
- Langkilde, Annette Eva;
- Nejsum, Lene N;
- Klipp, Edda;
- Edwards, Robert;
- Kragelund, Birthe B;
- Jensen, Poul Henning;
- Nissen, Poul
Publication type:
Article
Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity.
Published in:
Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40478-015-0185-3
By:
- Stewart, Tessandra;
- Sossi, Vesna;
- Aasly, Jan O.;
- Wszolek, Zbigniew K.;
- Uitti, Ryan J.;
- Hasegawa, Kazuko;
- Yokoyama, Teruo;
- Zabetian, Cyrus P.;
- Leverenz, James B.;
- Stoessl, Alexander Jon;
- Yu Wang;
- Ginghina, Carmen;
- Changqin Liu;
- Cain, Kevin C.;
- Auinger, Peggy;
- Un Jung Kang;
- Jensen, Poul Henning;
- Min Shi;
- Jing Zhang
Publication type:
Article
Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity.
Published in:
Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40478-015-0185-3
By:
- Tessandra Stewart;
- Vesna Sossi;
- Aasly, Jan O.;
- Zbigniew K. Wszolek;
- Ryan J. Uitti;
- Kazuko Hasegawa;
- Teruo Yokoyama;
- Cyrus P. Zabetian;
- James B. Leverenz;
- Stoessl, Alexander Jon;
- Yu Wang;
- Carmen Ginghina;
- Changqin Liu;
- Cain, Kevin C.;
- Auinger, Peggy;
- Un Jung Kang;
- Jensen, Poul Henning;
- Min Shi;
- Jing Zhang
Publication type:
Article
Endoplasmic Reticulum-Based Calcium Dysfunctions in Synucleinopathies.
Published in:
Frontiers in Neurology, 2021, v. 12, p. 1, doi. 10.3389/fneur.2021.742625
By:
- Kovacs, Gergo;
- Reimer, Lasse;
- Jensen, Poul Henning
Publication type:
Article
Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein.
Published in:
PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0116473
By:
- Betzer, Cristine;
- Movius, A. James;
- Shi, Min;
- Gai, Wei-Ping;
- Zhang, Jing;
- Jensen, Poul Henning
Publication type:
Article
An Exonic Insertion Encodes an Alanine Stretch in Porcine Synapsin I.
Published in:
Biochemical Genetics, 2009, v. 47, n. 11/12, p. 812, doi. 10.1007/s10528-009-9279-6
By:
- Hedegaard, Claus;
- Bendixen, Emøke;
- Jensen, Poul Henning;
- Bendixen, Christian;
- Larsen, Knud
Publication type:
Article
Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.
Published in:
Journal of Neurochemistry, 2021, v. 158, n. 4, p. 960, doi. 10.1111/jnc.15432
By:
- Vecchio, Laura M.;
- Sullivan, Patricia;
- Dunn, Amy R.;
- Bermejo, Marie Kristel;
- Fu, Rong;
- Masoud, Shababa T.;
- Gregersen, Emil;
- Urs, Nikhil M.;
- Nazari, Reza;
- Jensen, Poul Henning;
- Ramsey, Amy;
- Goldstein, David S.;
- Miller, Gary W.;
- Salahpour, Ali
Publication type:
Article
Multiple Protective Roles of Nanoliposome‐Incorporated Baicalein against Alpha‐Synuclein Aggregates.
Published in:
Advanced Functional Materials, 2021, v. 31, n. 7, p. 1, doi. 10.1002/adfm.202007765
By:
- Aliakbari, Farhang;
- Mohammad‐Beigi, Hossein;
- Abbasi, Shahsanam;
- Rezaei‐Ghaleh, Nasrollah;
- Lermyte, Frederik;
- Parsafar, Soha;
- Becker, Stefan;
- Tafreshi, Azita Parvaneh;
- O'Connor, Peter B.;
- Collingwood, Joanna F.;
- Christiansen, Gunna;
- Sutherland, Duncan S.;
- Jensen, Poul Henning;
- Morshedi, Dina;
- Otzen, Daniel E.
Publication type:
Article
Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.
Published in:
EMBO Reports, 2018, v. 19, n. 5, p. 1, doi. 10.15252/embr.201744617
By:
- Betzer, Cristine;
- Lassen, Louise Berkhoudt;
- Olsen, Anders;
- Kofoed, Rikke Hahn;
- Reimer, Lasse;
- Gregersen, Emil;
- Zheng, Jin;
- Calì, Tito;
- Gai, Wei‐Ping;
- Chen, Tong;
- Moeller, Arne;
- Brini, Marisa;
- Fu, Yuhong;
- Halliday, Glenda;
- Brudek, Tomasz;
- Aznar, Susana;
- Pakkenberg, Bente;
- Andersen, Jens Peter;
- Jensen, Poul Henning
Publication type:
Article
Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates.
Published in:
Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. 1, doi. 10.1186/s40478-019-0865-5
By:
- Elfarrash, Sara;
- Jensen, Nanna Møller;
- Ferreira, Nelson;
- Betzer, Cristine;
- Thevathasan, Jervis Vermal;
- Diekmann, Robin;
- Adel, Mohamed;
- Omar, Nisreen Mansour;
- Boraie, Mohamed Z.;
- Gad, Sabry;
- Ries, Jonas;
- Kirik, Deniz;
- Nabavi, Sadegh;
- Jensen, Poul Henning
Publication type:
Article
Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein.
Published in:
PLoS ONE, 2021, v. 16, n. 10, p. 1, doi. 10.1371/journal.pone.0252635
By:
- Elfarrash, Sara;
- Jensen, Nanna Møller;
- Ferreira, Nelson;
- Schmidt, Sissel Ida;
- Gregersen, Emil;
- Vestergaard, Marie Vibeke;
- Nabavi, Sadegh;
- Meyer, Morten;
- Jensen, Poul Henning
Publication type:
Article
Stabilization of α-synuclein oligomers using formaldehyde.
Published in:
PLoS ONE, 2019, v. 14, n. 10, p. 1, doi. 10.1371/journal.pone.0216764
By:
- Ruesink, Harm;
- Reimer, Lasse;
- Gregersen, Emil;
- Moeller, Arne;
- Betzer, Cristine;
- Jensen, Poul Henning
Publication type:
Article
Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy.
Published in:
Journal of Cellular & Molecular Medicine, 2021, v. 25, n. 20, p. 9634, doi. 10.1111/jcmm.16910
By:
- Cui, Hengjing;
- Kilpeläinen, Tommi;
- Zouzoula, Lydia;
- Auno, Samuli;
- Trontti, Kalevi;
- Kurvonen, Sampo;
- Norrbacka, Susanna;
- Hovatta, Iiris;
- Jensen, Poul Henning;
- Myöhänen, Timo T.
Publication type:
Article
Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity.
Published in:
2021
By:
- Gregersen, Emil;
- Betzer, Cristine;
- Kim, Woojin S.;
- Kovacs, Gergo;
- Reimer, Lasse;
- Halliday, Glenda M.;
- Thiel, Steffen;
- Jensen, Poul Henning
Publication type:
journal article
Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson's Disease.
Published in:
NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-024-00750-x
By:
- Kapucu, Fikret Emre;
- Tujula, Iisa;
- Kulta, Oskari;
- Sukki, Lassi;
- Ryynänen, Tomi;
- Gram, Hjalte;
- Vuolanto, Valtteri;
- Vinogradov, Andrey;
- Kreutzer, Joose;
- Jensen, Poul Henning;
- Kallio, Pasi;
- Narkilahti, Susanna
Publication type:
Article
Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson's Disease.
Published in:
NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-024-00750-x
By:
- Kapucu, Fikret Emre;
- Tujula, Iisa;
- Kulta, Oskari;
- Sukki, Lassi;
- Ryynänen, Tomi;
- Gram, Hjalte;
- Vuolanto, Valtteri;
- Vinogradov, Andrey;
- Kreutzer, Joose;
- Jensen, Poul Henning;
- Kallio, Pasi;
- Narkilahti, Susanna
Publication type:
Article
Structural and functional characterization of two alpha-synuclein strains.
Published in:
Nature Communications, 2013, v. 4, n. 10, p. 2575, doi. 10.1038/ncomms3575
By:
- Bousset, Luc;
- Pieri, Laura;
- Ruiz-Arlandis, Gemma;
- Gath, Julia;
- Jensen, Poul Henning;
- Habenstein, Birgit;
- Madiona, Karine;
- Olieric, Vincent;
- Böckmann, Anja;
- Meier, Beat H.;
- Melki, Ronald
Publication type:
Article
PKR kinase directly regulates tau expression and Alzheimer's disease‐related tau phosphorylation.
Published in:
Brain Pathology, 2021, v. 31, n. 1, p. 103, doi. 10.1111/bpa.12883
By:
- Reimer, Lasse;
- Betzer, Cristine;
- Kofoed, Rikke Hahn;
- Volbracht, Christiane;
- Fog, Karina;
- Kurhade, Chaitanya;
- Nilsson, Emma;
- Överby, Anna K.;
- Jensen, Poul Henning
Publication type:
Article
Protein Partners of α-Synuclein in Health and Disease.
Published in:
Brain Pathology, 2016, v. 26, n. 3, p. 389, doi. 10.1111/bpa.12374
By:
- Lassen, Louise Berkhoudt;
- Reimer, Lasse;
- Ferreira, Nelson;
- Betzer, Cristine;
- Jensen, Poul Henning
Publication type:
Article
Axonal transport of synucleins is mediated by all rate components.
Published in:
European Journal of Neuroscience, 1999, v. 11, n. 10, p. 3369, doi. 10.1046/j.1460-9568.1999.00754.x
By:
- Jensen, Poul Henning;
- Li, Jia‐Yi;
- Dahlström, Annica;
- Dotti, Carlos G.
Publication type:
Article
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.
Published in:
PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0160501
By:
- Matrone, Carmela;
- Dzamko, Nicolas;
- Madsen, Peder;
- Nyegaard, Mette;
- Pohlmann, Regina;
- Søndergaard, Rikke V.;
- Lassen, Louise B.;
- Andresen, Thomas L.;
- Halliday, Glenda M.;
- Jensen, Poul Henning;
- Nielsen, Morten S.
Publication type:
Article
Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting α‐Synuclein.
Published in:
Movement Disorders, 2023, v. 38, n. 3, p. 378, doi. 10.1002/mds.29318
By:
- Jensen, Poul Henning;
- Schlossmacher, Michael G.;
- Stefanis, Leonidas
Publication type:
Article
Correction to: Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.
Published in:
2019
By:
- Mavroeidi, Panagiota;
- Arvanitaki, Fedra;
- Karakitsou, Anastasia-Kiriaki;
- Vetsi, Maria;
- Kloukina, Ismini;
- Zweckstetter, Markus;
- Giller, Karin;
- Becker, Stefan;
- Sorrentino, Zachary A.;
- Giasson, Benoit I.;
- Jensen, Poul Henning;
- Stefanis, Leonidas;
- Xilouri, Maria
Publication type:
Correction Notice
Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats.
Published in:
Acta Neuropathologica, 2019, v. 138, n. 4, p. 535, doi. 10.1007/s00401-019-02040-w
By:
- Van Den Berge, Nathalie;
- Ferreira, Nelson;
- Gram, Hjalte;
- Mikkelsen, Trine Werenberg;
- Alstrup, Aage Kristian Olsen;
- Casadei, Nicolas;
- Tsung-Pin, Pai;
- Riess, Olaf;
- Nyengaard, Jens Randel;
- Tamgüney, Gültekin;
- Jensen, Poul Henning;
- Borghammer, Per
Publication type:
Article
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.
Published in:
Acta Neuropathologica, 2019, v. 138, n. 3, p. 415, doi. 10.1007/s00401-019-02014-y
By:
- Mavroeidi, Panagiota;
- Arvanitaki, Fedra;
- Karakitsou, Anastasia-Kiriaki;
- Vetsi, Maria;
- Kloukina, Ismini;
- Zweckstetter, Markus;
- Giller, Karin;
- Becker, Stefan;
- Sorrentino, Zachary A.;
- Giasson, Benoit I.;
- Jensen, Poul Henning;
- Stefanis, Leonidas;
- Xilouri, Maria
Publication type:
Article
Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.
Published in:
Cells (2073-4409), 2022, v. 11, n. 22, p. 3673, doi. 10.3390/cells11223673
By:
- Lassen, Louise Berkhoudt;
- Thomsen, Maj Schneider;
- Basso, Elisa;
- Füchtbauer, Ernst-Martin;
- Füchtbauer, Annette;
- Outeiro, Tiago Fleming;
- Jensen, Poul Henning;
- Moos, Torben
Publication type:
Article
Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson’s Disease and Synucleinopathies.
Published in:
Frontiers in Neuroscience, 2018, p. 1, doi. 10.3389/fnins.2018.00819
By:
- Betzer, Cristine;
- Jensen, Poul Henning
Publication type:
Article
Calcium(II) selectively induces α-synuclein annular oligomers via interaction with the C-terminal domain.
Published in:
Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 12, p. 3245, doi. 10.1110/ps.04879704
By:
- Lowe, Rachel;
- Pountney, Dean L.;
- Jensen, Poul Henning;
- Gai, Wei Ping;
- Voelcker, Nicolas H.
Publication type:
Article
Identification of multiple post-translational modifications in the porcine brain specific p25α.
Published in:
Journal of Neurochemistry, 2008, v. 106, n. 2, p. 925, doi. 10.1111/j.1471-4159.2008.05437.x
By:
- Kleinnijenhuis, Anne J.;
- Hedegaard, Claus;
- Lundvig, Ditte;
- Sundbye, Sabrina;
- Issinger, Olaf Georg;
- Jensen, Ole Nørregaard;
- Jensen, Poul Henning
Publication type:
Article
AXONAL TRANSPORT OF SYNUCLEIN.
Published in:
1999
By:
- Jensen, Poul Henning;
- Li, J.-Y.;
- Dahlström, A.;
- Dotti, C. G.
Publication type:
Abstract
Structural basis of epitope recognition by anti-alpha-synuclein antibodies MJFR14-6-4-2.
Published in:
NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-024-00822-y
By:
- Liekniņa, Ilva;
- Reimer, Lasse;
- Panteļejevs, Teodors;
- Lends, Alons;
- Jaudzems, Kristaps;
- El-Turabi, Aadil;
- Gram, Hjalte;
- Hammi, Anissa;
- Jensen, Poul Henning;
- Tārs, Kaspars
Publication type:
Article
ELISA method to detect α-synuclein oligomers in cell and animal models.
Published in:
PLoS ONE, 2018, v. 13, n. 4, p. 1, doi. 10.1371/journal.pone.0196056
By:
- Lassen, Louise Berkhoudt;
- Gregersen, Emil;
- Isager, Anne Kathrine;
- Betzer, Cristine;
- Kofoed, Rikke Hahn;
- Jensen, Poul Henning
Publication type:
Article

Found: 43